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A revolutionary new solution in the fight against wrinkles. Unlike other traditional peptide therapies which act only on collagen production and hyaluronic acid production, Rejuvan8 combines traditional proven formulas with a new innovation in transdermal peptide therapy, a transdermal, no needle product which has a botox-like effect. The tri-peptide works directly on the n-M-acetyl choline receptors, creating a true relaxing effect of the muscle. The regular use as a daily moisturizer creates a cumulative effect of facial muscles to have a long term smoothing result.

Directions for Use

Apply morning and evening by warming a small amount of rejuvaDERM’s Rejuvan8 in the palms of your hands, to throroughly cleansed face and neck using light sweeping movements, followed by light pressing motions, avoiding the eye contour area.


D-alpha Tocopherol Acetate Vitamin E Moisturising and anti-oxidant properties.
Dipeptide Diaminobutyroyl
Benzylamide Diacetate
A tripeptide that was developed for efficient smoothing and anti-wrinkle care, and to be particularly effective against expression lines by relaxing facial muscles. The active tripeptide acts in a manner similar to Waglerin-1, a neuromuscular blocking compound of the venom of the Temple viper.1
Palmitoyl Oligopeptide
Palmitoyl Tetrapeptide-3
  Contains matrikines that are messengers of cutaneous restructuration and repair they activate the neosynthesis of extracelluar matrix macromolecules providing a visible anti-wrinkle efficacy.
Imperata Cylindrica (Root Extract)   Imperata cylindrical provides the skin with considerable hydration. Potassium and DMSP help cells maintain their osmotic equilibrium. The synergistic effect has been exploited to produce a high, immediate and long-lasting moisturizing effect.

PH Levels: 5.5 – 6.0 Size: 40ml

Clinical Data: Syn®-ake

SYN®-AKE is a new anti-wrinkle active compound based on a synthetic tripeptide that mimics the effect of waglerin 1, a peptide that is found in the venom of the Temple Viper.

Temple Viper

muscle contraction and relaxation


  • SYN®-AKE is an excellent anti-wrinkle active compound with a snake venom-like mode of activity. SYN®-AKE smooths mimic wrinkles in a short period.

Cosmetic applications:

  • Age killing effect particularly effective against expression lines
  • Intensive anti-wrinkles care

Efficacy Tests
In vitro tests:

The efficacy of the SYN®-AKE tripeptide (at a concentration of 0.5mM) has been demonstrated in vitro by measuring the frequency of contraction of the innervated muscle cells as a function of the incubation time.

contraction frequencies

SYN®-AKE peptide reduces muscle cell contraction and its ction is reversible.

In vitro tests

The measurement of the smoothing and anti-wrinkle effect of SYN®-AKE (4%) was compared to a placebo. A cream was applied to the forehead twice daily during 28 days.

wrinkle reduction

SYN®-AKE – Age Killing Effect.

The smoothing effect Ra) was measured on 80% of the volunteers and the anti-wrinkle effect (Rz, Rt) measured on 73% of the volunteers.

Results showed up to - 52% of wrinkle size after 28 days application!